Sign Out
Hypersensitivity to the active substances or to any of the excipients listed in Description.
Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
Diabetic pre-coma.
Severe renal failure (GFR < 30 ml/min) (see Precautions).
Acute conditions with the potential to alter renal function, such as: dehydration, severe infection, shock, intravascular administration of iodinated contrast agents (see Precautions).
Acute or chronic disease which may cause tissue hypoxia, such as: cardiac or respiratory failure, recent myocardial infarction, shock.
Hepatic impairment (see Dosage & Administration, Precautions and Adverse Reactions).
Acute alcohol intoxication, alcoholism.
Breast-feeding (see Use in Pregnancy & Lactation)
